The Japan Flavor and Fragrance Materials Association (JFFMA) has reported the designation of three flavoring substances by the Ministry of Health Labor and Welfare. This designation means that the flavoring substances are legally permitted for use in flavors in Japan, effective immediately.
The substances are 5-methyl-6, 7-dihydro-5H-cyclopentapyrazine (FEMA# 3306, CAS# 23747-48-0, JECFA# 781), 2-(3-phenylpropyl)pyridine (FEMA# 3751, CAS# 2110-18-1, JECFA# 1321) and 2,3-diethyl-5-methylpyrazine (FEMA# 3336, CAS# 18138-04-0, JECFA# 777).
For more information on these substances, this IOFI information letter is available. Additionally, this letter notes more designations are underway as the result of an effort sponsored by the IOFI Science Board to achieve acceptance in Japan of substances that are in international use but do not fit in any of the 18 structural groups currently used in the Japanese regulation of chemically defined substances.
!['[R]etaining this next generation will depend on continuing to position flavor science as a field where individuals can combine scientific excellence with creativity and real-world impact, shaping how consumers experience food in ways that improve both health and sustainability,' says John Savage, IOFI president and president and CEO of Taste at Kerry.](https://img.perfumerflavorist.com/mindful/allured/workspaces/default/uploads/2026/07/john-savage.Cws5vQDBLp.jpg?auto=format%2Ccompress&fit=crop&h=191&q=70&w=340)









