![Holger Moustakas, Ph.D., shared, “[Endpoint specificity in read-across analog selection] expands the potential read-across options RIFM scientists have, which allows them to ensure the safety of more fragrance ingredients while avoiding extra testing and saving animal lives.”](https://img.perfumerflavorist.com/files/base/allured/all/image/2023/01/dreamstime_xxl_215632720.63bd7023dee7e.png?auto=format%2Ccompress&q=70&w=700)
In 2022, the Research Institute for Fragrance Materials (RIFM) had a record-breaking year in terms of research papers being published in peer-reviewed journals.
One of the 12 published papers was penned by RIFM’s Computational Chemistry lead scientist Holger Moustakas, Ph.D., alongside a team of RIFM scientists and Expert Panel for Fragrance Safety members, published “An Endpoint-Specific Framework for Read-Across Analog Selection for Human Health Effects” in the peer-reviewed journal Chemical Research in Toxicology.
Read-across is a safety assessment approach in which study data on one chemical can be used as a proxy to support the safe use of a structurally similar chemical lacking study data.
Moustakas discussed the importance and impact of the research, “Endpoint specificity in read-across analog selection makes read-across a more scientific process. In addition, it expands the potential read-across options RIFM scientists have, which allows them to ensure the safety of more fragrance ingredients while avoiding extra testing and saving animal lives.”
