RIFM Publishes Endpoint-Specific Read-Across Paper on Fragrance Ingredient Testing

In 2022, the Research Institute for Fragrance Materials (RIFM) had a record-breaking year in terms of research papers being published in peer-reviewed journals. 

One of the 12 published papers was penned by RIFM’s Computational Chemistry lead scientist Holger Moustakas, Ph.D., alongside a team of RIFM scientists and Expert Panel for Fragrance Safety members, published “An Endpoint-Specific Framework for Read-Across Analog Selection for Human Health Effects” in the peer-reviewed journal Chemical Research in Toxicology.

Read-across is a safety assessment approach in which study data on one chemical can be used as a proxy to support the safe use of a structurally similar chemical lacking study data.

Moustakas discussed the importance and impact of the research, “Endpoint specificity in read-across analog selection makes read-across a more scientific process. In addition, it expands the potential read-across options RIFM scientists have, which allows them to ensure the safety of more fragrance ingredients while avoiding extra testing and saving animal lives.”