Gerstel has published a new pharmacokinetic study on anticonvulsants employing the Gerstel Dried Blood Spot Autosampler (DBS-A).
The Gerstel DBS-A was found to be a valuable tool for pharmacokinetic studies, helping to reduce cost of sampling and sample shipment while improving data quality since repeat or more frequent blood sampling is feasible without the need for healthcare professionals to perform the sampling.
The study presents the automated determination of carbamazepine, its metabolite carbamazepine-10,11-epoxide and gabapentin in dried blood spots (DBS) using the Gerstel DBS-A coupled online to LC-MS/MS.
The analysis method was employed to demonstrate the feasibility of pharmacokinetic studies with this type of instrumentation.
Concentration vs. time curves were recorded for the analytes in real dried blood samples from a volunteer person after application of a single oral dose of each drug. Data generated were in agreement with pharmacokinetic data from scientific literature.
The complete study is available on the Gerstel website.
