The Chemistry of F&F: Physiological Coolants

Similarly, the main aroma may be the first thing one tastes, while a cooling sensation gradually builds up. Finally, there is the coolant that coats the mouth or skin, leaving one with a refreshed feeling.

In the past 30 years, a tremendous amount of research has taken place in the development of compounds that have a “cooling” effect. Wilkinson Sword was probably the most prolific in the early days, evaluating more than 1,200 compounds for a cooling sensation. To this day, three of these compounds are still successful commercial products. The synthesis of one of these materials, N-ethyl-p-menthane-3-carboxamide.

All of these materials are solids, which potentially can make formulations more difficult due to possible solubility problems. Although flavorists and perfumers have been able to formulate around these potential issues, it is clear that new materials are always welcome in order to avoid such problems. In addition, under Japanese legislation, they cannot be added to foodstuff because amides are not permitted in foodstuffs (see

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