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EFSA Rules Out Genotoxic Concerns for Five α,β-Unsaturated Flavorings

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Based on new data, the European Food Safety Authority's (EFSA) panel on food contact materials, enzymes, flavorings and processing aids has concluded that 2,6-dimethyl-2,5,7-octatriene-1-ol acetate [FL-no: 09.931] does not indicate concerns in respect to genotoxicity. 

This panel said this conclusion can also be applied to the four substances 12-beta-santalen-14-ol [FL-no: 02.216], 12-alpha-santalen-14-ol [FL-no: 02.217], santalyl acetate [FL-no: 09.034] and santalyl phenylacetate [FL-no: 09.712] from FGE.19 subgroup 2.1 for which 2,6-dimethyl-2,5,7-octatriene-1-ol acetate [FL-no: 09.931] is representative. All five substances have the α,β-unsaturation in an aliphatic side-chain and are methylated in the α-position of the α,β-unsaturation.

This new study was requested after an evaluation of Flavouring Group Evaluation (FGE) 207, corresponding to subgroup 2.1 of FGE.19, indicated concerns in regards to the evaluation of genotoxicity data submitted on one α,β-unsaturated flavoring substance, 2,6-dimethyl-2,5,7-octatriene-1-ol acetate [FL-no: 09.931], from subgroup 1.1.2 of FGE.19 (FGE.201), which is considered to be representative for four substances, 12-beta-santalen-14-ol [FL-no: 02.216], 12-alpha-santalen-14-ol [FL-no: 02.217], santalyl acetate [FL-no: 09.034] and santalyl phenylacetate [FL-no: 09.712], from subgroup 2.1 of FGE.19.

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