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Special Feature: REACH and In Vitro Alternatives—Corrosive Potential Testing

Posted: November 28, 2007

page 4 of 7

Once the viability of the tissues has been determined at each time point, the final classification of a test material as corrosive or noncorrosive with the tissue modela is determined (Table 1).

The in vitro skin models have proven themselves to be a most useful in vitro tool for testing the skin corrosion potential of chemicals. A follow-up column will expand on the function of skin tissue equivalents and discuss their usefulness as alternative in vitro tests for two additional markers: skin irritation and phototoxicity. Stay tuned.


Send correspondence to Robert Holz

1. T Hofer et al, Animal testing and alternative approaches for the human health risk assessment under the proposed new European chemicals regulation, Archives of Toxicol 78(10), 549-564 (2004)