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Special Feature: REACH and In Vitro Alternatives—Corrosive Potential Testing
Posted: November 28, 2007
page 4 of 7
Once the viability of the tissues has been determined at each time point, the final classification of a test material as corrosive or noncorrosive with the tissue modela is determined (Table 1).
The in vitro skin models have proven themselves to be a most useful in vitro tool for testing the skin corrosion potential of chemicals. A follow-up column will expand on the function of skin tissue equivalents and discuss their usefulness as alternative in vitro tests for two additional markers: skin irritation and phototoxicity. Stay tuned.
Send correspondence to Robert Holz.
1. T Hofer et al, Animal testing and alternative approaches for the human health risk assessment under the proposed new European chemicals regulation, Archives of Toxicol 78(10), 549-564 (2004)