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Special Feature: REACH and In Vitro Alternatives—Corrosive Potential Testing

Posted: November 28, 2007

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7. L Phillips, M Steinberg, HI Mailbach, WA Akers, A comparison of rabbit and human skin response to certain irritants, Toxicol Appl Pharmacol 21 369-382 (1972)

8. MK Robinson, C Cohen, AB de Fraissinette, M Ponec, E Whittle, JH Fentem, Non-animal testing strategies for assessment of the skin corrosion and skin irritation potential of ingredients and finished products, Food Chem Toxicol 40(5) 573-592 (2002)

Table 1. Mean tissue viability (percent of negative control)

C/NC  Predicted
< 50% at 3 min corrosive
> 50% at 3 min and < 15% at 1 hr corrosive
> 50% at 3 min and > 15% at 1 hr noncorrosive

Draize rabbit skin test