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Research from Monell, Integral Molecular Displays Bitterness Inhibition

Posted: June 3, 2011

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Researchers then undertook a series of human sensory studies showing how probenecid significantly inhibited the bitter taste of salicin, a compound that stimulates one of the target receptors. “This demonstrates how we can take experiments in vitro and go on to show how they make a difference functionally and perceptually,” said Breslin.

Continuing studies on this topic will investigate TAS2Rs with the goal of identifying the regions of the receptors that contribute to bitter molecule binding and how binding events lead to signaling events within the cell.