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Organosilicon Fragrances

Contact Author Dr. Jozef Gora
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Novel and interesting investigations in the field of the chemistry of odor have been recently described by Wrobel and Warmagat. In their search for new fragrances and for a better understanding of the relationship between the molecular structure and the olfactory propeties of compounds, the authors turned their attention to silicon. The principal approach was to introduce the silicon atom into the osmophoric center of odoriferous materials. A number of compounds have been prepared and evaluated. This article briefly summarizes the synthesis and olfactory characteristics obtained.

Silicon Analogues of Tertiary Alcohols

For the preparation of tertiary dialkyl aromatic silanols, the Grignard route was the synthetic pathway of choice (see figure 1). The yields of individual synthetic steps ranged between 24% and 89%.

Silyl linalool was prepared in the manner shown in figure 2. The yields of individual steps ranged from 44-63%.

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