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Allergic Contact Dermatitis to Linalool

By: Jurij Hostynek and Howard Maibach, University of California School of Medicine
Posted: April 22, 2008, from the May 2008 issue of P&F magazine.

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  • From P&F Magazine
  • May 2008 issue, pg. 52—4 pages
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Linalool has otherwise been cited as a moderately frequent cause of allergic contact dermatitis.

This article reviews the published data on the allergenicity of linalool (3,7-dimethyl-1,6-octadien-3-ol; CAS# 78-70-6; EINECS 201-134-4) (F-1) relating to its relative potency as a skin sensitizer. A semiquantitative evaluation of the different reports cited below has been made in accordance with the system outlined in Maibach et al.,1 which is based on the procedures proposed by Benezra et al.2 and describes the scoring system used for assigning the degree of confidence in data reported.

Other topics discussed: Methods; Results; Predictive tests using animals; Predictive tests using human volunteers; Clinical diagnostic patch tests on patients; Evidence that Autoxidation Leads to Allergenic By-products; Comment; Conclusions

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