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By: Michael Zviely
Posted: April 10, 2009, from the May 2009 issue of P&F magazine.

3-(4-Ethylphenyl)-2,2-dimethylpropionaldehyde (F-1) is a colorless to pale yellow liquid, which exists as the main isomer (60–80%) in the product consisting of an ortho isomer (15–35%) and a meta isomer (ca. 5%) (F-2). It is prepared by condensation of 1-chloromethyl-4-ethylbenzene (tech.) with isobutyraldehyde in the presence of a phase transfer catalyst as shown in F-3.1,2

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